The utility model discloses a valve base and a ball valve with the valve base, and belongs to the technical field of valves. The valve base comprises a valve base body. An elastic piece is arranged on the valve base body. The valve base body and the elastic piece are of an integrated structure. A working sealing face is arranged at the end of the elastic piece. The valve base is ingenious in design and simple and reasonable in structure, pressure of media is utilized for pushing the elastic piece of the valve base to be in reliable sealing connection with the spherical surface of a valve element, the valve base has the advantage that the larger the pressure of the media is, the more reliable the sealing is, and the sealing problem with high pressure difference and high leakage is solved; when the valve base is assembled, the sealing faces of a valve element and the valve base are easily in contact, and flow-open installation is adopted, so that the valve is opened easily and flexibly, no starting tripping phenomenon is generated, the torque of an actuator is small, the cost is low, and the phenomenon that the valve element and the valve base are prone to occlusion and clamping on the high-temperature working condition is avoided compared with the traditional flow-closed installation design.