The utility model discloses a wine packaging box which comprises a lifting handle, a middle partition board, box partition chambers and a box bottom. The middle partition board is positioned between the two lateral box partition chambers positioned in the two sides of the middle partition board and connected with the box bottom, the box bottom is connected with the box partition chambers, and the lifting handle is positioned on the middle partition board. The wine packaging box is made of energy-saving and environment-friendly materials, can be applied to occasions of supermarkets, bars, senior clubs and the like, and is wide in application range and high in practicability. The packaging box can be stored conveniently to save space and be expanded directly in use. The design of an automatic bottom buckling type is adopted in the bottom of the packaging box, firm adhesion is achieved, and wine bottles in the box can not fall off. The packaging box is provided with the lifting handle, and a customer can lift the packaging box conveniently by means of a handhold hole in the middle of a box body.